Sensitization to Morphine-Induced Potentiation of Brain Stimulation Reward: Reversal by DNQX
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چکیده
منابع مشابه
Role of the Orexinergic System Within the Ventral Tegmental Area in the Development of Sensitization to Morphine Induced By Lateral Hypothalamus Stimulation
The lateral hypothalamus (LH) has long been known to implicate in the addictive behaviors of drugs of abuse. The ventral tegmental area (VTA) is a major area of the mesolimbic system that is strongly involved in the development of morphine sensitization. The current study aimed to examine the role of intra-VTA orexin receptors in the LH stimulation-induced sensitization to the antinociceptive r...
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The effect of theta pulse stimulation (TPS) on pentylenetetrazol (PTZ)-induced long-term potentiation of population spikes (PS) was studied in the hippocampal CA1 in vitro. A transient PTZ application produced a long-lasting enhancement of PS amplitude. A 3-min episode of TPS delivered at a higher intensity produced complete reversal of the PTZ potentiation when delivered during the last minute...
متن کاملRole of adenosine receptors and protein phosphatases in the reversal of pentylenetetrazol-induced potentiation phenomenon by theta pulse stimulation in the CA1 region of rat hippocampal slices
The effect of theta pulse stimulation (TPS) on pentylenetetrazol (PTZ)-induced long-term potentiation of population spikes (PS) was studied in the hippocampal CA1 in vitro. A transient PTZ application produced a long-lasting enhancement of PS amplitude. A 3-min episode of TPS delivered at a higher intensity produced complete reversal of the PTZ potentiation when delivered during the last minute...
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Effect of four calcium channel blockers (CCBs) belonging to different chemical classes, alone and in combination with morphine was investigated on two models of pain sensitivity, i.e. formalin and tail flick tests in mice. All the studied CCBs, i.e. diltiazem, flunarizine, nimodipine and verapamil inhibited formalin-induced pain responses; however, with verapamil, though there was a trend towar...
متن کاملBrain Stimulation Reward
In 1953, Olds and Milner discovered that rats would readily learn to work for electrical stimulation of certain brain sites. Their findings inspired a large body of research on the neural basis of reward, motivation, and learning. Unlike consummatory behaviors, which satiate as a result of ingestion of and contact with the goal object, performance for rewarding brain stimulation is remarkably s...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 1994
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1380232